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KMID : 0377220010260020018
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Medical Journal of Chosun Univercity
2001 Volume.26 No. 2 p.18 ~ p.26
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p53 Expression and Detection of Epstein-Barr Virus in Laryngeal and Hypopharyngeal Squamous Cell Carcinoma
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Choi Young-Hwan
Do Nam-Yong
Na Han-Jo
Lee Do-Yong
Rho Yong-Hun
Kim Wan-Su
Choi Jong-Sun
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Abstract
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Background and Objectives : When p53 cancer suppressor gene, occurs gene deletion or point mutation, malignancy develops by loss of p53 function with abnormal p53 protein. The Epstein-Barr virus (EBV) is the causative agent of certain type of lymphoma and undifferentiated nasopharyngeal carcinoma. However, the role of EBV as a causative factor in other head &eck tumors is not fully elucidated except nasopharyngeal carcinoma. This study, the author examined that p53 expression and detection rate of EBV correlate to development of laryngeal and hypopharyngeal squamous cell carcinoma(SCC) and play the possible role of prognostic indicators.
Materials and Methods : Formalin-fixed, paraffin-embedded tissue specimen from 32 cases of larynx and hypopharyngeal squamous cell carcinomas were studied by immunohistochemical staining for p53 and EBV. The results of analysis were compared with clinicopathological parameters.
Results : p53 expression was 56.3% (18 cases) and the detection rate of EBV was 43.6% (14 cases) of 32 cases in laryngeal and hypopharyngeal squamous cell carcinomas. p53 expression was correlate with histologic grade (p<05) only. Detection of EBV was not correlate with clinicopathological parmeters.
Conclusion : These results suggest p53 expression and the detection of EBV may be related with development of laryngeal and hypopharyngeal squamous cell carcinoma. And, the expression of p53 protein can be used as a prognosticator in laryngeal and hypopharyngeal squamous cell carcinoma under certain limitation.
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KEYWORD
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Protein p53, EBV, Squamous cell carcinoma, Immunohistochemistry
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